San Juan de Dios opened the first nursing school in the country in 1913 because of the need to open a nursing school that would train students in technical nursing service. They opened the Bachelor of Science in Medical Technology course and Liberal Arts course in 1965.
It was changed into San Juan de Dios College after 60 years and added the course Medical Technology to the list of offered programs. They relocated the Hospital and College to Dewey Boulevard (now Roxas Boulevard) after the original hospital was converted into the Lyceum of the Philippines University in Intramuros on December 12, 1953.
San Juan de Dios Hospital and College became an educational foundation on April 17, 1991. During this period, the college began a new baccalaureate course, Bachelor of Science in Physical Therapy.
They opened Senior High School (Grades 11 and 12) program with strands of Humanities and Social Sciences (HUMSS), Science, Technology, Engineering and Mathematics (STEM), Accountancy, Business and Management (ABM), General Academic Strand (GAS), and Technological and Vocational Livelihood (TVL) in 2016. They introduced 2 new business courses, Bachelor of Science in Office Administration and Bachelor of Science in Entrepreneurship, in 2019. The General Academic Strand (GAS) was discontinued permanently due to the huge number of classrooms.
San Juan de Dios Educational Foundation, Inc. (SJDEFI or SJ, formerly Hospital de San Juan de Dios started out as a hospital in 1578. The hospital is considered the oldest hospital in the Philippines. It is named after San Juan de Dios, a Portuguese-born soldier that turned health-care worker of Spain.
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