On February 11, 1945, the Philippine Civilian Assitance Unit, established an indigent children's clinic in the building of the defunct bureau of public welfare at San Rafael St., Manila. Under the leadership of Dr. Victoria Kalaw-Linan take care of the war refugees, the sick, and undernourished children.
In 1952, republic act No. 731 changed the name of indigent childrens's Hospital to National Indigent Children's Hospital. Republic Act 948, In 1953 was passed appropriating funds for the construction of the Hospital Building Subsequently Republic Act 1340 amended republic act 731 changing the name of the Nation of Indigent Children's Hospital to its present name The National Children's Hospital.
National Children's Hospitla has continually grown, evolved and expanded with the changing times the hospital has been the front runner in the care of pediatric patients, in the different stages of life and different types of diseases.